162
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Determination of Citalopram in Tablets by HPLC, Densitometric HPTLC, and Videodensitometric HPTLC Methods

&
Pages 313-324 | Received 12 Aug 2004, Accepted 20 Sep 2004, Published online: 22 Aug 2007
 

Abstract

Three simple, rapid, and accurate analytical methods for the determination of citalopram in tablets were developed. The high performance liquid chromatography method was carried out using Waters Nova‐Pak C18 column with a mobile phase composed of methanol–0.067 M phosphate buffer pH 2.00 (55:45, v/v), UV‐VIS detector at 239 nm, and moclobemide as the internal standard. High performance thin layer chromatography was performed on silica gel 60F254 HPTLC plates with a mixture of benzene–acetone–ethanol–25% aqueous ammonia (45:40:10:5, v/v/v/v) as a mobile phase. The detection and quantification were carried out at 226 nm (densitometry) and 254 nm (videodensitometry). The linearity range for the HPLC method was 5–50 µg/mL and for both HPTLC methods was 0.2–3.2 µg per spot. The RSD values obtained for the standard solutions were <2.0% for HPLC, <2.4% for densitometry, and <2.9% for videodensitometry. The recovery values obtained for the model mixtures were between 99.47% and 102.70%, between 102.17% and 104.44%, and between 100.74% and 104.01%, respectively.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 583.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.