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Original Articles

Reversed Phase Liquid Chromatographic Method for the High‐Throughput Analysis of Clopidogrel in Pharmaceutical Formulations Using a Monolithic Silica Column

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Pages 1357-1365 | Received 27 Nov 2004, Accepted 24 Dec 2004, Published online: 06 Feb 2007
 

Abstract

A high‐throughput, high performance liquid chromatographic method was developed and validated for the determination of clopidogrel in pharmaceutical dosage forms. The analysis was performed at room temperature using a reversed phase monolithic silica column Chromolith Performance 18e (100 mm×4.6 mm I.D.). The mobile phase consisted of acetonitrile:phosphate buffer (50∶50 v/v, pH 3.0) at a flow rate of 4.0 mL/min. The photodiode array detector was set at 235 nm. The developed method showed a good linear relationship in the concentration range from 1.0 to 40.0 µg/mL with a correlation coefficient of 0.999. The limit of detection and limit of quantification were 0.97 µg/mL and 3.52 µg/mL, respectively.

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