Controlled Drug Release from Gelatin-Sodium Carboxymethylcellulose Interpenetrating Polymer Networks

Abstract

Hydrogels of uncrosslinked gelatin, crosslinked gelatin (Gelx), and various compositions of semi-interpenetrating polymer network of cross-linked gelatin with uncross-linked sodium carboxymethylcellulose [Gelx-NaCMC] were investigated as potential matrices for substrate delivery. Simultaneous swelling behavior and controlled drug release under enzymatic conditions (erodible) were monitored for hydrogels of [Gelx-NaCMC] and Gelx. Results indicated a first order release indicating that the processes (rate of drug diffusion and degradation) do not follow the same kinetics.

Keywords:

• Hydrogels
• Swelling
• Drug release
• Enzymatic degradation
• Biodegradation
• Natural polymers
• Gelatin
• Interpenetrating polymers networks

Acknowledgment

G. V. N. Rathna acknowledges the University of Grants Commission (UGC), New Delhi, for financial assistance in the form of a fellowship.