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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

SYNTHESIS AND ANTICANCER ACTIVITY OF 4-AMINO-5-OXO-8-(β-D-XYLOFURANOSYL) PYRIDO[2,3-d]PYRIMIDINE

Zbigniew Pietrzkowski Cancer Biology Laboratories, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California, 92626, U.S.A.
,
Jean-Luc Girardet Chemistry, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California, 92626, U.S.A.
,
Cathey Esler Cancer Biology Laboratories, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California, 92626, U.S.A.
&
Guangyi Wang Chemistry, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California, 92626, U.S.A.
Pages 323-328 | Published online: 07 Feb 2007
 
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Abstract

4-Amino-5-oxo-8-(βD-xylofuranosyl)pyrido[2,3-d]pyrimidine (4) was recently synthesized and evaluated in our laboratories for anticancer activities. This compound showed potent in vitro inhibitory effects on the growth of HTB-81 prostate cancer cells and Daudi-lymphoma. In vivo studies showed that the compound could inhibit HTB-81 tumor growth in syngeneic mice by 93% at a daily dose of 8.5 mg/kg for 10 days.

Acknowledgments

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