SYNTHESIS OF 5-CHLORO-1-(2,3-DIDEOXY-3-FLUORO-β-D-GLYCERO-HEX-2-ENOPYRANOSE-4-ULOSYL)URACIL AS POTENTIAL ANTICANCER/ANTIVIRAL AGENT

Abstract

Peracetylated α-D-glucose was coupled with silylated 5-chlorouracil. The product (2) was deacetylated and 4′,6′-hydroxyls were then protected with 4′,6′-O-isopropylidene group. Fluorine was introduced at the 3′-position, followed by acetylation, deprotection, tritylation, oxidation and deritylation of subsequent compounds gave the target compound (10).

^*Undergraduate student sponsored by the Minority Biomedical Research Support Program.

ACKNOWLEDGMENT

Financial support from NIGMS through Minority Biomedical Research Support Program grant number SO6 GM 08111 is gratefully acknowledged.

Notes

^*Undergraduate student sponsored by the Minority Biomedical Research Support Program.