Abstract
1,2,3-Tri-O-acetyl-N-ethyl-β-D-ribofuranuronamide was synthesized in three steps starting from 1-O-methyl-(2,3-O-isopropylidene)-β-D-ribofuranuronic acid. Both the triacetyl and the 1-O-methyl-2,3-di-O-acetyl derivatives were coupled to the 2,6-dichloropurine to obtain the acetylated 1-(2,6-dichloro-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-erythro-pentofuranuronamide. 1H NMR and n.O.e. data accounted for both anomeric and N-7/N-9 isomeric configuration.
ACKNOWLEDGMENTS
Financial support by the Italian Ministry of Research (Grant n° 9905155535, 1999) and by the University of Camerino (Fondo di Ricerca d'Ateneo 1999) is gratefully acknowledged.