Abstract
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH 2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
ACKNOWLEDGMENT
The work was supported by grants No. NL5441-3 (G.A. of Czech Ministry of Health) and No. A4055902 (G.A. of the Czech Acad. Sci.). The authors are indebted to Dr. Ivana Kavenová for a perfect technical assistance.