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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

SYNTHESIS AND EVALUATION OF α-LNA

Nanna K. Christensen Department of Chemistry, University of Southern Denmark, Odense M, 5230, Denmark
,
Jakob K. Dalskov Department of Chemistry, University of Southern Denmark, Odense M, 5230, Denmark
&
Paul Nielsen Department of Chemistry, University of Southern Denmark, Odense M, 5230, Denmark
Pages 825-828 | Published online: 07 Feb 2007
 
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Abstract

Three different synthetic routes to the α-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four α-LNA monomers into α-DNA had a destabilizing effect on the duplexes. However, a fully modified α-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.

ACKNOWLEDGMENT

The Danish Natural Science Research Council is thanked for financial support.

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