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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IS RESPONSIBLE FOR INTRANUCLEAR LOCALIZATION OF SOME OLIGONUCLEOTIDES

V. Tomasi Institute of Cytomorphology, C.N.R., Bologna, Italy
,
P. P. Laktionov Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemisty, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia
,
A. V. Bryksin Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemisty, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia
,
N. V. Volod'ko Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemisty, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia
,
C. Griffoni Institute of Cytomorphology, C.N.R., Bologna, Italy
,
E. Y. Rykova Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemisty, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia
,
E. Spisni Institute of Cytomorphology, C.N.R., Bologna, Italy
,
R. Kraft
&
V. V. Vlassov Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemisty, 8 Lavrentiev Ave., Novosibirsk, 630090, RussiaCorrespondence[email protected]
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Pages 863-867 | Published online: 07 Feb 2007
 
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Abstract

Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.

Acknowledgments

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