SITE-DIRECTED ALKYLATION TO CYTIDINE WITHIN DUPLEX BY THE OLIGONUCLEOTIDES CONTAINING FUNCTIONAL NUCLEOBASES

Abstract

We have previously described that oligonucleotides (ODN) containing phenylsulfoxide derivative of 2-amino-6-vinylpurine nucleoside analog (1) are activated within duplex to form cross-link toward cytidine selectively at the target site. In this paper, we wish to report the search for more stable precursor susceptible for activation within duplex.

Acknowledgments