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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

SYNTHESIS OF N2-ALKYLGUANOSINE USING MITSUNOBU REACTION AS A KEY STEP

Tokumi Maruyama Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan
,
Aya Yorikane Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan
&
Shigetada Kozai Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan
Pages 935-936 | Published online: 07 Feb 2007
 
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Abstract

Peracetylated guanosine was reacted with POCl3 to give an 2-acetamido-6- chloro-9H-purine derivative, which was condensed with primary or secondary alcohols to give N 2-alkylated analogues. The products were treated with mercaptoethanol in the presence of sodium methoxide to afford N 2-alkylguanosines.

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