Abstract
Syntheses of the monomer building blocks used for the solid-phase synthesis of specifically 1′-13C-labeled oligoribonucleotides from the D-[1-13C]ribose is presented. Procedure has been used for the selective formation of 2′-O-silylated ribonucleosides. After 5′-O-dimethoxytritylation, the synthesis of D-[1′-13C] ribonucleoside phosphoramidites has been achieved.
ACKNOWLEDGMENT
This work was supported by a research grant from the CNRS (Grant ACC Physique Chimie du Vivant). We gratefully acknowledge the Region Centre and the Studium for a postdoctoral fellowship.