Abstract
Two synthetic approaches were used for preparation of 8-amino-, 8-methyl- amino-, and 8-dimethylaminoadenine and -guanine analogs of PME and HPMP series: (a) direct modification of 8-bromopurine acyclic nucleotide analogs at the 8-position of the base, (b) alkylation of 8-modified purine bases with alkylation agents.
ACKNOWLEDGMENTS
This study was supported by the Czech State Grant Agency (grant #203/96/K001) and by Gilead Sciences (Foster City, CA, USA).