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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

MODIFIED CYCLOBUTANE CARBONUCLEOSIDES: SYNTHESIS AND EVALUATION OF THEIR ANTIVIRAL ACTIVITY

F. Fernández Universidad de Santiago, Dpto. Química Orgínica, Facultad de Farmacia, Santiago de Compostela, E-15706, Spain
,
A. R. Hergueta Universidad de Santiago, Dpto. Química Orgínica, Facultad de Farmacia, Santiago de Compostela, E-15706, Spain
,
C. López Universidad de Santiago, Dpto. Química Orgínica, Facultad de Farmacia, Santiago de Compostela, E-15706, Spain
,
E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium
&
J. Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium
Pages 1129-1131 | Published online: 07 Feb 2007
 
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Abstract

The synthesis of some 9-(2-cyclobutylethyl)guanine derivatives and analogous carbonucleosides from 1S-α-pinene is here presented. None of them showed detectable selectivity when assayed in the performed anti-viral tests.

Acknowledgments

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