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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

SYNTHESIS AND EVALUATION OF PROLYL CARBAMATE NUCLEIC ACIDS (PrCNA)

Meena Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India
,
V. A. Kumar Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India
&
K. N. Ganesh Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India
Pages 1193-1196 | Published online: 07 Feb 2007
 
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Abstract

Carbamate linked prolyl nucleic acids are obtained in high yield and purity under mild conditions in solution and solid phase. p-Nitrophenylchloroformate is used as the activating reagent for alcohol. Homooligomers of PrCNA do not bind to DNA. The introduction of this modification in PNA sequences destabilizes the triplxes, inspite of enhancement in the base stacking.

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