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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

BRIDGED CYCLIC OLIGORIBONUCLEOTIDES—TOWARDS MODELS FOR CODON-ANTICODON PAIRING

R. Micura Institute of Chemistry, University of Linz, Altenbergerstr. 69, Linz, A-4040, Austria
,
W. Pils Institute of Chemistry, University of Linz, Altenbergerstr. 69, Linz, A-4040, Austria
,
K. Grubmayr Institute of Chemistry, University of Linz, Altenbergerstr. 69, Linz, A-4040, Austria
,
M.-O. Ebert Laboratory of Organic Chemistry, ETH, Universitätsstr. 16, Zürich, CH-8092, Switzerland
&
B. Jaun Laboratory of Organic Chemistry, ETH, Universitätsstr. 16, Zürich, CH-8092, Switzerland
Pages 1287-1289 | Published online: 07 Feb 2007
 
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Abstract

Only three base pairs make up for stable double helices of regular A-type if both helix ends are bridged by flexible non-nucleotide linkers. These cyclic oligoribonucleotides are used as model systems for codon-anticodon pairing in order to reveal base stacking effects arising from structurally relevant bases in the direct neighbourhood of the core triplet duplex.

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