KINETIC STUDIES OF THE DEGRADATION OF OXYCARBONYLOXYMETHYL PRODRUG OF ADEFOVIR AND TENOFOVIR IN SOLUTION

Abstract

The decomposition kinetics of bis-POC PMEA and bis-POC PMPA followed pseudo-first order kinetics with the corresponding mono-POC ester detected as the only observable degradation product for all the pH values studied.The rates of hydrolysis of bis-POC PMEA over the pH range studied was described by $$ The ¹⁸O incorporation studies revealed that hydrolysis of bis-POC PMEA at pH 7.0 primarily proceeds via P-O cleavage with an additional minor pathway involving C‒O bond cleavage. Hydrolysis of bis-POC PMPA was found to be about 2 fold slower than bis-POC PMEA at pH values above 6.0.

Acknowledgments