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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

AMPHIPHILIC β-SHEET PEPTIDES CAN BIND TO DOUBLE AND TRIPLE STRANDED DNA

Kinuko Yokoyama Department of Chemistry, School of Engineering, Molecular Engineering Institute Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan
,
Takanori Kubo Department of Chemistry, School of Engineering, Molecular Engineering Institute Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan
&
Masayuki Fujii Department of Chemistry, School of Engineering, Molecular Engineering Institute Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan
Pages 1317-1320 | Published online: 07 Feb 2007
 
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Abstract

It was shown that synthetic peptides with amphiphilic β-sheet structure can bind to and stabilize double and triple stranded DNA. CD spectra indicated that β-sheet conformation of peptides were emphasized in the presence or absence of DNA and that no significant change of DNA conformation occurred. UV melting study at pH 7.0 revealed that interaction of peptides with DNA and its hybrids are sensitive and specific depending the host structure.

Acknowledgments

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