THE SYNTHESIS OF, AND STUDIES ON, 2′-C-MODIFIED NUCLEOTIDES

Abstract

The synthesis of uridine monomers containing either a 2′-deoxy-2′-C-methy- lcyano or ethylcyano group is described. These monomers are intended for incorporation into oligonucleotides to investigate a proposed duplex-stabilising effect exerted by 2′-tethered amide groups.

ACKNOWLEDGEMENTS

We would like to thank the EPSRC for a studentship to LB and the EPSRC service at Swansea for obtaining mass spectra.