Abstract
An efficient synthesis of cyclic ADP-carbocyclic-ribose (2), as a stable mimic for cyclic ADP-ribose, was achieved. Treatment of N 1-carbocyclic-ribosyla-denosine bisphosphate derivative 10 with AgNO3 in the presence of molecular sieves 3A in pyridine gave the desired cyclic product in 93% yield, which was deprotected to give the target cyclic ADP-carbocyclic-ribose (2).
ACKNOWLEDGEMENT
This investigation was supported in part by a Grant from the Ministry of Education, Science, Sports, and Culture of Japan.