PREPARATION OF 3′-C-BRANCHED URIDINE ANALOGUES, SUITABLE FOR CONVERSION INTO FUNCTIONALISED 3′-C-METHYLENE DERIVATIVES

Abstract

A novel method for preparation of 1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-hydroxymethyl-5-O-monomethoxytrityl-β-D-ribo-pentofuranosyl]uracil by hydroboration of corresponding 3′-deoxy-3′-C-methyleneuridine derivative has been developed. Further conversion of the hydroxyl function into different leaving groups was carried out to afford derivatives suitable for conversion into various 3′-C-branched uridine analogues through substitution.

ACKNOWLEDGEMENTS

We thank the Swedish Natural Science Research Council and the Swedish Research Council for Engineering Sciences for financial support.