ABSTRACT
Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.
Acknowledgments
This work was supported by the Danish National Research Councils (grant. no. 9501145) to H.F. and J.H.R. We thank Dr. C. Nielsen for performing the antiviral tests.