Abstract
Phosphonate derivatives of acyclovir containing phosphorous acid and ethoxycarbonylphosphonic acid residues as well as their isopropyl esters were prepared. They selectively inhibited the herpes simplex virus 1 reproduction in Vero cell culture, the efficacy of esters being 3–4 times higher than that of ACV. The hydrolysis of the synthesized compounds was studied in the PBS buffer and human blood serum.
Acknowledgment
The work was supported by the Russian Foundation for Basic Research, projects No. 01-04-48627, No. 02-04-49009, and No. 02-04-06525.