Abstract
Treatment of sugar‐protected 2‐N‐trityl derivatives of guanosine and 2′‐deoxyguanosine with imidazole/triphenylphosphine/iodine/ethyldiisopropylamine gives the corresponding 6‐(imidazol‐1‐yl)‐2‐(tritylamino)purine nucleosides. SNAr displacement of the imidazole moiety with nucleophiles provides 2‐amino‐6‐substituted‐purine nucleosides and 2′‐deoxynucleosides.
†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
#This paper is: Nucleic Acid Related Compounds, 122. Paper 121 is Ref. Citation1.
Acknowledgments
We are grateful for Graduate Research Fellowships from Brigham Young University (X.L.) and pharmaceutical company gift funds (M.J.R.) for financial support.
Notes
†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
#This paper is: Nucleic Acid Related Compounds, 122. Paper 121 is Ref. Citation1.