Abstract
Synthesis and adenosine deaminase (ADA) inhibitory activity of two analogues of coformycin, containing the imidazo[4,5‐e][1,2,4]triazepine ring system, have been reported as part of the structure‐activity relationship (SAR) studies to explore the factors responsible for the extremely tight‐binding characteristics of coformycins to ADA.
†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
Acknowledgments
This research was supported by a grant (#9 RO1 AI55452) from the National Institutes of Health. Authors thank Dr. Diana S. Hamilton for advice regarding the reported enzyme kinetics studies.
Notes
†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
aMolecular modeling studies were performed using Insight/DiscoverTM Software package, available from Molecular Simulations, Inc., San Diego, California.