Expression of the MDR1 and MRP Genes in Patients with Lymphoma with Primary Bone Marrow Involvement

Abstract

Expression of MDR1 and MRP genes in patients with low‐grade and high‐grade non‐Hodgkin's lymphomas with primary bone marrow involvement before and after chemotherapy was investigated. The data demonstrate that overexpression of MDR1 and MRP genes in hematological malignancies elevates in patients after chemotherapy and correlates with poor clinic prognosis and more frequent recurrences of the malignancies.

Keywords:

• Multi‐drug resistance
• Lymphoma
• Chemotherapy

Acknowledgment

This work was supported by grant from RFBR No. 03‐04‐48550, grant from CRDF No. 0‐008‐X1, Interdisciplinary grant of SB RAS No. 50, grant from RAS in the frame of program “Gen‐targeted biologically active compounds.”