Abstract
o‐Bromobenzoic acid was found to promote copper‐dependent reactive oxygen species formation from molecular oxygen, resulting in DNA base modification and backbone cleavage. The oligonucleotide conjugate bearing 5‐(4′‐aminopropyl‐sulfomoyl)‐2‐bromobenzoic acid as a reactive group was synthesized and DNA cleavage activity of this oligonucleotide conjugate was tested on a model deoxyoligonucleotide.
Acknowledgment
The research was supported by Russian Government Program “Gene‐directed biologically active compounds.”