Thermodynamics of Interaction of Phthalocyanine‐Oligonucleotide Conjugates with Single‐ and Double‐Stranded DNA

Abstract

Thermodynamics of interaction of phthalocyanine‐oligonucleotide conjugates with single‐ and double‐stranded DNA resulting in formation of duplexes and triplexes was measured by UV melting method. It was shown that a phthalocyanine moiety of conjugates stabilized the formation of duplexes and triplexes.

Keywords:

• Phthalocyanines
• PDT
• Oligonucleotide conjugates
• DNA duplexes and Triplexes
• Thermodynamics

Acknowledgments

This work was supported by the grant from the President of Russia for support of leading scientific schools, by RFBR (grant No. 02‐04‐48080), by Russian National Program on Gene‐Directed Biologically Active Compounds, by the Integration grant from the Russian Academy of Sciences (No. 10.6) and by Novosibirsk Regional Foundation for Support of Science and High Education. V. V. K. was supported by grant (No. Y1‐B‐08‐16) from CRDF and from the Russian Ministry of Education within the Program “Basic Research and High Educaton.”