Abstract
A new strategy for engineering of catalytic two‐component constructions based on 10–23 DNAzyme was proposed. The using of a combination of shortened DNAzyme with 2′‐O‐methyl oligomers as effectors significantly increased the catalytic activity of this DNAzyme.
Acknowledgments
We thank Dr. D.V. Pyshnyi for the synthesis of oligodeoxyribonucleotides.
This work was supported by the Russian State Program “Gene Targeted Biologically Active Compounds as Antiviral ad Anticancer Drugs,” SB RAS Integration Program (grant No. 50), RFBR (project No. 02‐04‐48586) and CRDF (project No. 008‐X1).