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Original Articles

MICROWAVES SYNTHESIS OF SOLID SUPPORTS FOR THE SYNTHESIS OF 3′-AMINOALKYL OLIGODEOXYNUCLEOTIDES

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Pages 623-627 | Published online: 15 Nov 2011
 

Abstract

Phthalimido-alkyl alcohol solid supports were rapidly prepared from solid supported phthalic anhydride and amino alcohol condensation induced by microwaves. These supports were used to synthesize 3′-aminoalkyl oligodeoxynucleotides allowing a two step deprotection necessary to avoid aminolink alkylation.

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