New Acyclonucleosides: Synthesis and Anti-HIV Activity

Abstract

The synthesis of new acyclic nucleosides is described. These syntheses were accomplished by various methods: glycosylation, selective or total deprotection, oxidation/reduction, chlorination or azidation of hydroxyl groups. The compounds were characterized with NMR, mass and IR spectroscopy. Antiviral properties of these compounds were evaluated on HIV-1 infected cell lines.

Keywords:

• Acyclonucleoside
• Selective Deprotection
• Azidation
• Chlorination

Notes

^a50% Effective concentration (mg/mL) or concentration required to inhibition the replication of HIV-1 by 50%.

^b50% Cytotoxic concentration (mg/mL) or concentration required to reduce the viability of uninfected cells by 50%.