Abstract
Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with pyrimidine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds 15–22 were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and HCMV.