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Preparative Biochemistry & Biotechnology Volume 34, 2004 - Issue 1
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Original Articles

Enzyme Catalyzed Synthesis of Some Vinyl Drug Esters in Organic Medium

De‐Shui Lv Department of Chemistry, Zhejiang University, 38#, Zheda Road, Hangzhou, 310027, P.R. China
,
Xing‐Tao Xue Department of Chemistry, Zhejiang University, 38#, Zheda Road, Hangzhou, 310027, P.R. China
,
Na Wang Department of Chemistry, Zhejiang University, 38#, Zheda Road, Hangzhou, 310027, P.R. China
,
Qi Wu Department of Chemistry, Zhejiang University, 38#, Zheda Road, Hangzhou, 310027, P.R. China
&
Xian‐Fu Lin Department of Chemistry, Zhejiang University, 38#, Zheda Road, Hangzhou, 310027, P.R. ChinaCorrespondence[email protected]
Pages 97-107 | Received 06 May 2003, Accepted 04 Jun 2003, Published online: 24 Aug 2007
 
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Abstract

A series of vinyl drug esters was synthesized using acyclovir and chloramphenicol with different carbon chain length acyl donors by alkaline protease from Bacillus subtilis and Lipozyme® respectively, in non‐aqueous medium. The corresponding vinyl drug derivatives were confirmed by nuclear magnetic resonance and infrared spectrometry. The influences of different organic solvents, reaction time, temperature, and content of water on synthesis of vinyl chloramphenicol esters were studied.

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