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Research Article

Release Behavior of Ketoprofen from Poly(Acryloyl-L-proline Methyl Ester) Gels Having Different Crosslinked Networks

, , , , , & show all
Pages 173-179 | Received 12 Nov 1999, Accepted 17 Aug 2000, Published online: 30 Apr 2001
 

Abstract

In order to clarify the relationship between the crosslinked structure of thermo-responsive polymer and drug release profile, polymer gels based on acryloyl-L-proline methyl ester (A-ProOMe) were synthesized in a mixture of water and acetone by the following two methods: a simultaneously occurring process of radiation-induced polymerization and crosslinking without a crosslinker (self-bridging method), and radiation-induced polymerization in the presence of the crosslinker tetradecaethylene glycol dimethacrylate (cosslinker method). The pronounced gap in thermo-response between two A-ProOMe gels, with an apparent degree of crosslinking of 11 for 1-propanol, shows a different shrinking pattern in the initial stage of time. The gels, which were obtained with the self-bridging method and the crosslinker method, were kept constant at a swelling ratio of 17 in water at 0°C for all systems. However, those values fell to 0.5 and 4, respectively, at 10 min after the temperature was increased to 37°C. The release mechanism of ketoprofen from two gel devices showed an anomalous (non-Fickian) transport, in which the release of ketoprofen with a low water-solubility could be directly related to the rapid release of water accompanying a gel shrinkage.

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