Medium Chain Triglycerides as Vehicle for Palatable Oral Liquids

Abstract

Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.

Keywords:

• Medium-chain triglycerides
• MCT
• Vehicle for pharmaceuticals
• Palatable oral liquids
• Masking the taste of drugs
• Efavirenz oral liquid

Notes

^aSt. David's Human Research Review Board (HRRB), One Radnor Corporate Center, Suite 300, Radnor, PA 19087.