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Research Article

Amlodipine Besylate–Excipients Interaction in Solid Dosage Form

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Pages 15-24 | Received 17 Jul 2002, Accepted 12 Apr 2003, Published online: 02 Apr 2004
 

Abstract

This article studies the compatibility of amlodipine besylate in its solid formulations with various drug excipients. The various factors affecting amlodipine besylate stability were studied using high‐performance liquid chromatography (HPLC). It has been found that binary 1:1 mixtures of amlodipine besylate and an excipient are stable at 65°C and 40°C/75% RH. Further investigations were conducted to study the stability of amlodipine besylate in multicomponent mixtures, including mixtures with actual formulations. The study reveals that mixtures of lactose, magnesium stearate, and water induce some instability on amlodipine besylate. The major degradation product confirmed by HPLC‐mass spectrometry is amlodipine besylate glycosyl. This is in conformity with the well‐known Maillard reaction between primary amines and lactose. Thus, lactose‐free amlodipine formulations are recommended from the safety, quality, efficacy, and process cost points of view.

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