Optimization of Formulation Parameters for the Preparation of Flutamide Liposomes by 3³ Factorial 26‐Term Logit Model

Abstract

This study deals with the study of the optimization of the volume of organic phase (X1), the volume of aqueous phase (X2), and the drug: phosphotidylcholine (PC): cholesterol (Chol) molar ratio (X3) using 3³ factorial 26‐term logit model to maximize the Flutamide absorption at the target site in the treatment of prostatic cancer by maximizing the entrapment of Flutamide (FLT) in the preparation of FLT liposomes. FLT liposomes are expected to be an excellent carrier for FLT to the prostatic cancer site based on the use of liposomes with other drugs. A 3³ factorial 26‐term logit model for coded factors X1, X2, and X3 is used to develop a second‐order response surface regression equation for predicting percent entrapment efficiency (%EE) for FLT. In turn, the regression equation is used to develop contour plots that show the %EE is maximized at the level of 1:15:2 of the drug:PC:Chol molar ratio with the volume of organic phase (chloroform:methanol) (1:2) at 5 mL and the volume of distilled water at 1.5 mL.

Keywords:

• Flutamide
• Liposomes
• Factorial design