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Journal of Receptors and Signal Transduction Volume 21, 2001 - Issue 1
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Research Article

EXPRESSION OF THE MT1 MELATONIN RECEPTOR SUBTYPE IN HUMAN CORONARY ARTERIES

Cem Ekmekcioglu Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria
,
Petra Haslmayer Department of Pathophysiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria
,
Catherina Philipp Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria
,
Mohammad R. Mehrabi Department of Cardiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria
,
Helmut D. Glogar Department of Cardiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria
,
Michael Grimm Department of Cardio-Thoracic Surgery, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria
,
Valentin J. Leibetseder Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria
,
Theresia Thalhammer Department of Pathophysiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria
&
Wolfgang Marktl Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria
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Pages 85-91 | Published online: 28 Feb 2001
 
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Abstract

Previous experimental data suggest a possible influence of melatonin on the circulatory system of animals after binding to G-protein coupled melatonin receptors. The present study sought to investigate whether the melatonin receptor, mt1, is expressed in human coronary arteries derived from healthy heart donors (n = 8). Expression of the mt1-receptor was studied in sections of isolated coronary arteries by a reverse transcriptase-polymerase chain reaction (RT-PCR) and Western immunoblot technique. The analyses of the results from both methods indicated the presence of the mt1-receptor in all of the subjects. Referring to these data we assume that melatonin regulates physiological processes in human coronary arteries after receptor binding.

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