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Journal of Receptors and Signal Transduction Volume 22, 2002 - Issue 1-4
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Research Article

THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS

Susanna Cotecchia Faculté de Médecine, Institut de Pharmacologie et Toxicologie, Rue du Bugnon 27, Lausanne, 1005, Switzerland
,
Katja Björklöf Faculté de Médecine, Institut de Pharmacologie et Toxicologie, Rue du Bugnon 27, Lausanne, 1005, Switzerland
,
Olivier Rossier Faculté de Médecine, Institut de Pharmacologie et Toxicologie, Rue du Bugnon 27, Lausanne, 1005, Switzerland
,
Laura Stanasila Faculté de Médecine, Institut de Pharmacologie et Toxicologie, Rue du Bugnon 27, Lausanne, 1005, Switzerland
,
Peter Greasley Faculté de Médecine, Institut de Pharmacologie et Toxicologie, Rue du Bugnon 27, Lausanne, 1005, Switzerland
&
Francesca Fanelli Dipartimento di Chimica, University of Modena and Reggio Emilia, Modena, 41100, Italy
Pages 1-16 | Published online: 11 Nov 2002
 
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ABSTRACT

The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the α1b-adrenergic receptor. Experimental and computational mutagenesis of the α1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the α1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.

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