A NEW SYNTHETIC APPROACH TO N,N′-DISUBSTITUTED 1,n-ALKANEDIAMINES

Abstract

A general procedure is described for the synthesis of unsymmetrically substituted N-aryl-N′-alky1 (or aryl) 1,n-alkanediamines 1 (n = 2−5) by reduction of ω-alkyl (or aryl) aminoalkanamides 2 with borane. Compounds 2 are easily obtained by aminolysis of the corresponding ω-haloalkanamides 3.

ACKNOWLEDGMENTS

This work was financially supported by the University of Buenos Aires and by CONICET. We are grateful to Mr. Fernando Niemevz for the preparation of some synthetic intermediates.