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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 7
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Original Articles

PRACTICAL SYNTHESIS OF ETHYL CIS-4-AMINO-3-METHOXY-1-PIPERIDINE CARBOXYLATE, A KEY INTERMEDIATE OF CISAPRIDE

, , , , , , & show all
Pages 1081-1089 | Received 07 Apr 2000, Published online: 09 Nov 2006
 

Abstract

A practical synthesis of ethyl cis-4-amino-3-methoxy-1-piperidinecarboxylate 1, a key intermediate of cisapride as a potent gastrointestinal stimulant, has been accomplished from 1-methyl-1,2,3,6-tetrahydropyridine 2 via an efficient formation of cis-fused oxazolidinopiperidine 7.

ACKNOWLEDGMENTS

We would like to thank Dong Wha Pharmaceutical Industry Co., Ltd, for financial support.

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