Abstract
A practical synthesis of ethyl cis-4-amino-3-methoxy-1-piperidinecarboxylate 1, a key intermediate of cisapride as a potent gastrointestinal stimulant, has been accomplished from 1-methyl-1,2,3,6-tetrahydropyridine 2 via an efficient formation of cis-fused oxazolidinopiperidine 7.
ACKNOWLEDGMENTS
We would like to thank Dong Wha Pharmaceutical Industry Co., Ltd, for financial support.