A FACILE SYNTHESIS OF N-ARYL AZIRIDINES

Abstract

Reaction of N-aryl-β-amino alcohols with p-toluenesulphonyl chloride under phase transfer catalytic condition gave the corresponding N-aryl aziridines in good yields, whereas N-alkyl-β-amino alcohol [for e.g., L-ephedrine] gave the corresponding N-tosyl derivative as the major product, along with the expected N-alkyl aziridines in lower yield.

ACKNOWLEDGEMENTS

The authors thank the UGC, New Delhi, for Special Assistance Programme; C.S.I.R., New Delhi, for Senior Research Fellowship (KS), R.S.I.C., I.I.T., Chennai; and Spic Science Foundation, Chennai, for NMR facilities.