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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 10
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Original Articles

A FACILE METHOD FOR THE SYNTHESIS OF 6-ALKYLATION PRODUCTS OF 1,3-DIALKYL-5-FLUOROURACIL

Jinzong You Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China
,
Shaoyuan Chen Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China
&
Yaozu Chen Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China
Pages 1541-1545 | Received 09 Aug 2000, Published online: 02 Aug 2010
 
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Abstract

6-Alkyl-1,3-diakyl-5-fluorouracil (3a–3f) were synthesized by the reaction of the lithium derivative of 1,3-dialkyl-5-fluorouracil with methyl iodide or alkyl trifluoromethanesulfonate. We found that the methylated products were ethyl-substituted derivatives, not methyl-substituted derivatives. A possible mechanism is also proposed for the ethylation process.

Acknowledgments

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