Abstract
An eudesmanolide sesquiterpene epoxide has been transformed to an α-hydroxy ketone with the salviane sesquiterpene skeleton through a novel carbon-carbon rearrangement promoted by excess of NaOMe in Et2O at room temperature which accomplished the first synthesis of the salviane kind of sesquiterpene skeleton. A possible reaction mechanism is also discussed.
ACKNOWLEDGMENTS
We are grateful for financial support from NNSFC(No. 29972019), FUKTME of China, the Young Teachers' Foundation of Ministry of Education and the Foundation of Ministry of Education (No. 99209).