ABSTRACT
The synthesis of a novel series of N-[1-alkyl(aryl)-3-oxo-4,4,4-trichloro(trifluoro)-1-buten-1-yl]-o-aminophenols and the analogous o-phenylenediamine derivatives [X3CC(O)CH=CR(o-NHC6H4Y), where X = F, Cl; R = H, Me, Et, aryl; and Y = NH2, OH] is reported.
ACKNOWLEDGMENTS
The authors are grateful for financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/PADCT III- Proj. 62.0228/97-0 - QEQ). Fellowships from CNPq (A. P. W.), are also acknowledged. Thanks are also due to the staff of the National Cancer Institute, Bethesda MD, USA, for the anticancer test reports.