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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 8
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Original Articles

A STEPWISE ONE POT SYNTHESIS OF ALKYL THIOPHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDES

Zhi-Wei Miao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China
,
Hua Fu The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China
,
Bo Han The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China
,
Yi Chen The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China
&
Yu-Fen Zhao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, ChinaCorrespondence[email protected]
Pages 1159-1167 | Received 12 May 2001, Published online: 16 Aug 2006
 
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ABSTRACT

Novel alkyl thiophosphoramidate derivatives of nucleoside analogues as membrane-soluble prodrugs of the bioactive free nucleotides have been prepared by phosphochloridothioate chemistry.

ACKNOWLEDGMENT

The authors would like to thank the financial support of the National Natural Science Foundation of China (No. 29902003, No. 39870415), the Ministry of Science and Technology, the Ministry of Education and Tsinghua University.

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