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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 8
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Original Articles

A PRACTICAL ONE POT SYNTHESIS OF 2-[2-(PYRIDYLMETHYL)-THIO]-1H-BENZIMIDAZOLES

, , , &
Pages 1211-1217 | Received 20 Sep 2000, Published online: 16 Aug 2006
 

ABSTRACT

A combination of Et3N and pTSCl was found to be far superior than pTSCl or benzene sulfonyl chloride alone in converting substituted 2-picoline-N-oxides to the corresponding 2-chloromethylpyridines and has been exploited for the synthesis of a variety of 2-[2-(pyridylmethyl)-thio]-1H-benzimidazoles, key intermediates in the manufacture of H+/K+-ATPase inhibitors in a single pot.

ACKNOWLEDGMENT

The authors wish to thank Dr. N. L. Gupta and Dr. B. N. Roy for constant encouragement and Mr. Ajay K. Tiwari and Mr. Charles D'souza for their expert assistance in the preparation of the manuscript.

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