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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 8
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Original Articles

PREPARATION OF METHYL ESTER DERIVATIVES OF AMINO ACIDS BEARING HYDROLYSABLE N-PROTECTION

Steve McGhie Chemical Development Division, GlaxoSmithKline, Temple Hill, Dartford, Kent, DA1 5AH, U.K.
Pages 1275-1278 | Received 16 Mar 2001, Published online: 16 Aug 2006
 
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ABSTRACT

A convenient method for the esterification of amino acids bearing labile N-substituents is described. Three compounds, 2(a–c), have been synthesised with retention of an N-trifluoroacetamide or an enamine group.

ACKNOWLEDGMENTS

The author would like to thank Jennifer Gilchrist for her guidance in the use of Biotage Flash 40 purification apparatus, Lynn Bogue (Spectroscopy) for carrying out the 1H NMR analysis and Butterworth Laboratory Limited for microanalysis.

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