SYNTHESIS OF N-(MORPHOLINOMETHYL) BENZAMIDES AS MOCLOBEMIDE ANALOGS

ABSTRACT

Syntheses of new morpholinomethylbenzamides 6 bearing both electron-withdrawing and electron-releasing groups at the aromatic ring are described. The strategy involved synthesis of hippuric acid ethyl esters 3, their hydrolysis to hippuric acids 4, subsequent oxidative decarboxylation to acetate 5 and morpholine addition to provide 6.

ACKNOWLEDGMENTS

We thanks to Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile y al Centro de Instrumentación CEPEDEQ, for access to the instruments.